[3] The school was founded by Jagatkishore Acharya Chowdhury, son of Vidyamoyee Devvya, as a gesture of love to his mother.

To keep the memory of his mother alive, Jagatkishore Acharya Chowdhury established Vidyamoyee Girls' High School in the district town in 1873 for female education.

The school was a red two-storied building on 3.5731 acres (14,460 m2) of land in the centre of Mymensingh town.

Some other landlords of Mymensingh like zamindars of Muktagacha, Gouripur and Krishnanagar came forward with financial support to fulfill the mission of Jagatkishore.

Sreemoti Bibhubala Bakshi succeeded Miss Verulkar in June 1928, serving in an officiating capacity until she was confirmed as permanent headmistress in May 1930.