[3] The mission of the Foundation was inspired by the couple's respective careers in biomedical science and art history, as well as their appreciation for the opportunities offered to them as newcomers to the United States.

[4] The Vilcek Prizes are awarded to foreign-born permanent residents of the United States, with significant accomplishments in the arts and sciences.

[6] The Vilcek Prizes for Creative Promise are awarded to foreign-born individuals who have demonstrated outstanding achievement during the early stages of their careers.

The 2019 Vilcek-Gold Award for Humanism in Healthcare was given to Dr. Mona Hanna-Attisha for her advocacy and interventions in addressing the water crisis in Flint, Michigan.

[101] In 2019, the Vilcek Foundation opened its new headquarters on Manhattan's Upper East Side, which includes two floors of gallery space.

In July 2022, the Vilcek Foundation supported the development and opening of the exhibition, Grounded in Clay: The Spirit of Pueblo Pottery at the Museum of Indian Arts and Culture in Santa Fe, New Mexico.

The exhibition was curated by a group of more than 60 artists, historians, and stewards of Native American art, the Pueblo Pottery Collective, and is accompanied by a catalogue from Merrell Publishers.

Curated by Emily Schuchardt Navratil, this landmark exhibition collected an extensive group of drawings, paintings, and photographs that document the influence of Crawford's experiences in the U.S. military on his life and work.

Ralston Crawford: Air + Space + War opened at the Brandywine River Museum of Art in June 2021, where it was on view through September 2021.

[111] Curated by Emily Schuchardt Navratil, Ralston Crawford: Torn Signs explores the national and international influences on the multifaceted Canadian-born artist.

To organize this unique exhibition, the Vilcek Foundation partnered with the Bates College Museum of Art, home to the Marsden Hartley Memorial Collection.

The Vilcek Foundation's former headquarters, also on the Upper East Side, was the host of exhibitions and events featuring the work of immigrant artists, designers, filmmakers, and others.