The structure is now owned by the Fondazione Sicilia and serves as their museum gallery and exhibition space for their collection of artworks, mainly graphic works and paintings, by mainly Sicilian artists from the 17th to the early 20th century.

The palace was originally at the site of a large semirural house owned by Gaspare Scicli in the first half of the 18th century.

He refurbished and expanded the palace in a Neo-Renaissance style in the early 20th-century using designs by the architect Michele La Cavera.

[1] On display in this pinacoteca are artists from various centuries, including Bernardo Strozzi, Mattia Preti, Luca Giordano, Salvator Rosa, Francesco Solimena, Ettore De Maria Bergler, Francesco Lojacono, Antonino Leto, Michele Catti, Aleardo Terzi, Camillo Innocenti; Mario Sironi, Filippo De Pisis, Boldini, Giuseppe De Nittis, Federico Zandomeneghi, Signorini, Ottone Rosai, Carlo Carrà, Arturo Tosi, Ugo Attardi, Fausto Pirandello, Renato Guttuso, Armando Pizzinato, Aleardo Terzi, Galileo Chini, Mario Schifano, and Corrado Cagli.

The archeologic, numismatic, philatelic, maiolica, and sculpture collections of the Fondazione, as well as a large library, are housed in the Palazzo Branciforte of Palermo.