Banco di Sicilia was an Italian bank based in Palermo, Sicily.

It was founded as Banco Regio dei Reali Domini al di là del Faro in 1849 and was renamed in 1860.

In 1997 it acquired Sicilcassa, at the same time the capital increase of Banco di Sicilia was subscribed by Mediocredito Centrale.

According to the Bank of Italy, Banco di Sicilia had market shares of 34% at that time in the island, in terms of branches.

As at 31 December 2009, Banco di Sicilia had a total assets of €14,921,651,349 and a shareholders' equity of €422,168,345.