Villers-Saint-Ghislain (Picard: Vilèr-Saint-Guilagne; Walloon: Vilé-Sint-Guilin) is a sub-municipality of the city of Mons located in the province of Hainaut, Wallonia, Belgium.

It was a separate municipality until 1977.

On 1 January 1977, it was merged into Mons.

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