Tyra replaced embattled Tom Jurich, who faced allegations of misconduct regarding the 2017–18 NCAA Division I men's basketball corruption scandal.
[8] In 1984, Tyra graduated from Trinity High School in Louisville and in 1988 he earned a Bachelor of Science degree in health administration from the University of Kentucky.
Over the years, he then served as Interim Chief Executive Officer of Total Fleet Solutions, Dealer Financial Services, and Elite Medical.
[16] On December 3, 2018, it was reported by The Courier-Journal that Tyra had hired Scott Satterfield as the new head coach of the Louisville Cardinals football team, replacing the fired Bobby Petrino.
[18] A few months later in May 2022 Tyra accepted an offer from Houchens Industries to become Senior Vice President, Corporate Strategy and Mergers and Acquisitions.