[1] He was selected by the Patriots in the second round of the 1993 NFL draft, the team's fourth selection after quarterback Drew Bledsoe, DL Chris Slade, and OL Todd Rucci during their re-building phase that started with the hiring of Bill Parcells.

He was given the nickname Vincent "Ultimate" Brisby by ESPN analyst Chris Berman.

He compiled 6 catches for 117 yards and two touchdowns in the Patriots 17–16 comeback win over the Green Bay Packers.

He injured his hamstring in pre-season that year and did not get into a game until Week 12, then missed two more games at which point his coach Bill Parcells was memorably quoted as saying that he himself had "recovered from open-heart surgery faster than he (Brisby) has (from the hamstring injury)...That's the truth.

After playing in only three regular season games and catching no passes at all in the regular season, divisional play-off, or AFC Championship, Brisby had two catches against the Green Bay Packers in Super Bowl XXXI.