During his spell with Enyimba International, he won the CAF Champions League twice, with one noteworthy distinction: He was always substituted before penalty shootouts.

Hapoel endured a poor season in 2007/2008, but Enyeama helped the team avoid relegation and reach the state cup final.

With the help of his two centre-backs, Marko Baša and Simon Kjær, Enyeama kept 11 consecutive clean sheets in Ligue 1 matches during the first half of the season.

In the 2017–18 season, Enyeama did not make a league appearance having been left out of the first team due to "a disagreement between the player and the club's management".

[10] While at the start of the 2019–20 season Enyeama stated that he hoped to find a new club and continue playing, he finally retired after the end of the campaign.

[11] After making his debut for the Nigeria national team against Kenya in May 2002,[12] Enyeama was selected for the 2002 FIFA World Cup as a cover for Ike Shorunmu.

[12] In the 2006 Africa Cup of Nations, Enyeama stopped three kicks in the quarter-final penalty shootout against Tunisia but could not prevent a loss to Ivory Coast in the semi-final.

In the 2010 tournament, he was again Nigeria's shootout hero at the quarter-final stage, saving from Zambia's Thomas Nyrienda and scoring the winning kick himself.

Enyeama, who was playing his 56th international for the Super Eagles, made six fine saves against the two-time world champions, four of them from Lionel Messi.

Enyeama was also awarded man of the match in the team's next fixture, a 2–1 loss to Greece but was at fault for Vasilis Torosidis' winning goal.

[12] On 10 February, Enyeama led Nigeria to its third continental victory, keeping a clean sheet in a 1–0 defeat of Burkina Faso in the 2013 Africa Cup of Nations Final.

[citation needed] In 2004, he was involved in a car accident in Uyo, Akwa Ibom State southern Nigeria, in which two motorcycle passengers were killed.