Vincent A. Fischetti is an American microbiologist and immunologist, and Head of the Laboratory of Bacterial Pathogenesis and Immunology at Rockefeller University in New York City.

[4][5] In 1989, the journal Science published Fischetti's research on developing a Streptococcus pyogenes vaccine using an M-protein-based approach, which was effective at preventing general streptococcal infections in a mouse model.

This information is now critical for the development of anti-infectives and vaccines, and allows for the surface location of molecules on the bacterial cell to be predicted from sequence data.

[14] In 2006, Fischetti was developing a lysin-based oral-nasal spray that can be delivered into the noses and mouths of hospital and nursing-home patients to prevent the impact of MRSA.

[21][22][23] Fischetti grew up in West Hempstead, Long Island, NY, and enrolled at Wagner College on a pre-dental track, before majoring in bacteriology and public health.

[2] He graduated in 1962, and went on to receive his master's degree in microbiology from Long Island University in 1967 whilst working at the McCarthy lab at Rockefeller.

[2] He later conducted postdoctoral research in the McCarty laboratory at Rockefeller University with John Zabriskie and Emil Gotschlich, focusing on streptococcal M protein, bacteriophage, and lysins.