He was a member of the avant-garde group Aksak Maboul (Onze Danses Pour Combattre la Migraine, 1977) and of The Honeymoon Killers, an experimental rock band (Les Tueurs de la Lune de Miel, 1982).
Closely associated with Belgian label Crammed Discs since its inception, both as an in-house producer and an A&R, he co-produced the seminal Noir et Blanc album by Zazou Bikaye (with Hector Zazou and Bony Bikaye, 1983), one of the first albums which blended electronic and African music.
Since 2004, Vincent Kenis has developed the Congotronics series (on Crammed Discs), which popularized electro-traditional music from the suburbs of Kinshasa (Democratic Republic of Congo).
The resulting albums (Congotronics, 2005, Live at Couleur Café, 2007 and Assume Crash Position, 2010) have earned the band worldwide recognition, as well as a BBC World Music Award (2006) and a nomination for a Grammy Award (2008).
Vincent Kenis' recent productions include an album by Malian Tuareg band Tartit (Abacabok, 2006), the multi-artist Congotronics 2 CD/DVD, featuring other Congotronics-style bands such as Kisanzi Kongo, Masanka Sankayi, Basokin, Konono N°1 and Kasai Allstars (Congotronics 2, 2006), the debut album by Kasai Allstars (In The 7th Moon, The Chief Turned into A Swimming Fish And Ate The Head of His Enemy By Magic, 2008), Très Très Fort (2009) and Bouger le monde (2012), the two albums by Kinshasa band Staff Benda Bilili, The Karindula Sessions (a DVD+CD documenting the music of 4 bands from south-eastern Congo), the latest albums by Kasai Allstars, Beware The Fetish (2014) and Around Félicité (2017), by Taraf de Haidouks, Of Lovers, Gamblers and Parachute Skirts (2015), and by Konono N°1, Konono N°1 Meets Batida (2016).