It is located in the Roman Catholic Diocese of San Diego The school serves approximately 300 students.

Vincent Memorial was established in 1949 as Our Lady of Guadalupe Academy, (OLGA) an all-girls school.

In addition, participation in a structured Christian service program is a requirement for graduation and may be completed prior to senior year.

Each semester, a special schedule is set up for administering of exams in each academic subject.

All other justified absences must obtain Administrative approval and make arrangements prior to exam date.

Vincent Memorial High is affiliated with the San Diego Southern Conference and participates in the Imperial Valley and Manzanita Leagues.