Cirilo B. Flores (June 20, 1948 – September 6, 2014) was an American prelate of the Roman Catholic Church who served as bishop of the Diocese of San Diego in California from 2013 until his death in 2014.

After graduating from Notre Dame High School in Riverside, California, in 1966, he studied at Loyola Marymount University in Los Angeles.

Feeling a returning call to the priesthood, he entered St. John's Seminary in Camarillo, California, in 1986, receiving a Master of Divinity (M.Div.)

"[8] On January 4, 2012, the apostolic nuncio to the United States announced that Flores had been named by Pope Benedict VI as the coadjutor bishop of the Diocese of San Diego, with immediate right of succession to San Diego bishop Robert Henry Brom, who reached his mandatory retirement age in 2013.

On April 16, 2014, Flores suffered a stroke in his office at the Pastoral Center and was rushed to a hospital, where he was said to be "alert and in good spirits".

He was not considered a good candidate for treatment and instead was receiving palliative care in San Diego.

At his bedside were his cousin Dr. Tom Martinez, Monsignor Steven Callahan and Sisters of Nazareth.