He has directed episodes of 45 different series, including Chicago PD, Agents of S.H.I.E.L.D., The Blacklist, The West Wing, Prison Break, Medium and Third Watch.
He became a regular director for the short-lived CBS drama Now and Again, directing seven first-season episodes over 1999 and 2000.
He also began a working relationship with ongoing series The West Wing and Third Watch.
Misiano continued his work on the fourth season of The West Wing into 2003 with a further episode.
In 2004 Misiano directed a fourth episode of The West Wing episode-7, "Change is Gonna Come," this time for the shows sixth season.
In fall 2006 he became involved with the second season of Fox action series Prison Break.
In fall 2008 Misiano returned to Eli Stone to direct a second-season episode.