[2] His cinematic influences included Samuel Beckett, David Cronenberg,[3] and Terry Gilliam.

[11] A May 2010 item in The Hollywood Reporter, however, announced that Natali was to replace Joseph Kahn as director of the highly anticipated adaptation of cyberpunk author William Gibson's 1984 novel Neuromancer.

[12] Natali was nominated for the 4th Annual Splatcademy Awards under the category "Best Director" presented by Cadaver Lab for his work Splice.

[14] in 2015, he also directed the second episode (entitled "Simon") of the first season of the American supernatural drama television series The Returned.

[15] A television adaptation of William Gibson's The Peripheral was put into development in April 2018 by Amazon,[16] with Natali among the executive producers.