Vincenzo Santopadre (born 11 August 1971) is an Italian former professional tennis player and a coach.

Since 2011 till the end of 2023, he was the coach of Matteo Berrettini, who has been ranked number 6 ATP, runner-up at Wimbledon, semifinalist at the US Open and the third Italian tennis player in history to have qualified for the ATP Finals.

At the Rome Masters, Santopadre achieved victories over 10th seed Karol Kucera in 1998 and defending champion Magnus Norman in 2001.

He reached the semifinals of Bournemouth in 1998 and the quarterfinals of Chennai and Munich in 1999, defeating Gustavo Kuerten in the latter.

He is the son-in-law of former Poland international footballer Zbigniew Boniek.