[1][3] De Cotiis has worked on projects involving public spaces and private residences,[4][5][6] as well as furniture design.

[7] He also collaborates with luxury brands, notably redesigning Burberry's flagship stores in London and Paris.

[11] He featured on Architectural Digest magazine's annual list of Top 100 designers worldwide in 2021, described as "following in the footsteps of Italian maestros like Gio Ponti and Carlo Scarpa.

[17] In 2023, De Cotiis completed architectural renovations of the 15th century Palazzo Giustinian Lolin, on Venice's Grand Canal,[18] as well as the restaurant and boardroom of the Grade-II listed Ladbroke Hall, Notting Hill, London.

[19] His work Ode is in the permanent collection of the FENIX Museum of Migration in Rotterdam.