[1] In 1846, Rudolf Virchow earned his medical license, and succeeded Robert Froriep as prosector at the Charité Hospital in Berlin.

In protest he established a new journal, then named Archiv für pathologische Anatomie und Physiologie und für klinische Medicin (Archives of Pathological Anatomy and Physiology and of Clinical Medicine), which he edited with his colleague Benno Reinhardt.

[3][4][5] He declared that the aim of the journal was to unite the branches of clinical medicine, pathological anatomy, and physiology.

[6][7] The first issue was published in February 1847 and contained only four articles – two by Virchow, one by Reinhardt, and one by Rud Leubuscher – and written entirely in German.

Its entire publication language became English by the late 1970s, and the long German name of the journal itself was deleted.