Pandurang Prabhu studied at Madras (Chennai) Law College, where he had a chance to read the Complete Works of Swami Vivekananda.
Vireshwarananda was sent to Varanasi, Orissa, Madras Presidency, Ceylon and other places to organize the workings of ashramas.
When Swami Madhavananda took leave from his office of the General Secretary on health grounds, Vireshwarananda officiated on his behalf from 1949 to 1951.
He introduced many philanthropic activities including rural development, 'Pallimangal' and training of youth in self-employment, 'Janashiksha', which encouraged the Order to venture into newer fields and thus expand its scope of service.
He translated into English many Sanskrit scriptures, including the gloss of Sridhara on the Bhagavadgita, the commentaries of Sankara and Ramanuja on Brahmasutra.