Born in Ianca, Brăila County, his parents were Ion Huzum, a pharmacist, and Clara (née Andoniu).
While a student, he published verses in Anuarul Societății literare a Liceului "Unirea"; he graduated in 1923.
He studied pharmacy and obtained a degree in literature and philosophy from the University of Bucharest in 1931.
Huzum's first published book was the 1926 À la manière de...., a collection of poetic parodies and pastiches.
This was followed by short collections of verse: Bolta bizantină (1929), Zenit (1936), Mirajul sunetelor (1973).