She was graduated in 1886 from the Woman's Medical College with the honors of her class, becoming one of the first female doctors in the United States, and remained in New York to practice.

[1] Meriwether conducted her medical work almost exclusively in connection with the New York Infant Asylum, where she served as resident physician for four years.

The institution had at the time the largest lying-in service conducted by women in the United States, and the lowest mortality and sick rates of any maternity wards in the world.

[2] In 1892, Meriwether married Arthur Bowen Davies (1862–1928), an initially unsuccessful, but later renowned, artist, whom she had met in 1890 while working as chief resident physician at the New York Infant Asylum.

Her parents bought her a farm which they had discovered together, although at one point she had considered buying the property with a woman called Lucile du Pre, who was reportedly very attracted to Meriwether.

When Arthur Davies died in 1928, Virginia discovered that he had kept hidden a second life, with another common-law wife, Edna, and family.

[4] The Virginia M. Davies Correspondence, 1891–1935 is preserved at Helen Farr Sloan Library & Archives, Delaware Art Museum.