Between Hopewell and Smithfield, which is served by SR 10 Business, the state highway passes through rural Prince George, Surry, and Isle of Wight counties, following the route of an old stagecoach road through an area that features many of the preserved James River plantations.

The state highway heads south along two-lane undivided Broad Rock Road, which continues north of the intersection as a city street.

The state highway intersects Warwick Road and Walmsley Boulevard while passing through the neighborhoods south of the railroad line, including Broad Rock.

SR 10's name changes to Iron Bridge Road shortly before exiting the city limits at its crossing of a reservoir along Falling Creek.

SR 10 continues south through Chesterfield Court House, where the highway passes through the county office complex and by the historic home Magnolia Grange.

The state highway meets the western end of SR 145 (Centralia Road) on the south side of the county seat.

[1][2] SR 10 continues east as West Hundred Road, which has an intersection with US 1 and US 301 (Jefferson Davis Highway) followed by a cloverleaf interchange with Interstate 95 (I-95, Richmond–Petersburg Turnpike).

The state highway heads southeast through the community of Rivermont before crossing the Appomattox River on the Charles Hardaway Marks Bridges into the city of Hopewell.

The state highway crosses Powell Creek at Garysville, which lies south of James River National Wildlife Refuge and Flowerdew Hundred Plantation.

The state highway traverses Lower Chippokes Creek and passes the Old Brick Church and Bacon's Castle, a rare American example of Jacobean architecture, in the namesake hamlet.

US 258 turns east onto Brewers Neck Road, which also carries SR 32, to head toward the James River Bridge to Newport News.

SR 10 Business continues north across the Pagan River and passes by the Smithfield Foods factory before leaving the town.