Just west of SR 105's western terminus, the westbound direction has a grade crossing with the Fort Eustis Military Railroad.

The state highway crosses Lee Hall Reservoir and CSX's Peninsula Subdivision railroad line.

SR 105 continues east along the southern edge of Newport News Park before entering York County, where the highway passes through a forested area with scattered residential subdivisions.

SR 105 reaches its eastern terminus at US 17 (George Washington Memorial Highway) between Yorktown to the north and Grafton to the south.

[1][2] In late 2009 the Virginia Department of Transportation began a widening project of SR 105 between Jefferson Avenue in Newport News and US 17 in York County.