The state highway runs 11.63 miles (18.72 km) from U.S. Route 60 (US 60) and SR 143 in the independent city of Hampton north to US 17 in Tabb.

[1][2] North of La Salle Avenue, SR 134 crosses Newmarket Creek and intersects US 258 (Mercury Boulevard).

Armistead Avenue continues north as an unnumbered street while the state highway turns west onto eight-lane Mercury Boulevard.

SR 134 runs concurrently with I-64 west to the partial interchange where the state highway exits to the north.

North of its single-point urban interchange with Hampton Roads Center Parkway, the state highway continues through a forested area and has a partial cloverleaf interchange with SR 172 (Commander Shepard Highway), which provides access to Langley Research Center and Langley Air Force Base.