The state highway runs concurrently with US 301 from Richmond to Bowling Green and with US 17 Business in the Fredericksburg area.

A short distance north of the city limits, the carriageways split, with the southbound lanes crossing to the west of Interstate 95 (I-95).

After I-95 veers northwest and the carriageways rejoin, SR 2 and US 301 pass through the suburb of Chamberlayne.

The two highways continue through a suburban area where they pass under CSX's Piedmont Subdivision.

US 301 leaves SR 2 on a two-way ramp to the bypass to head toward the Potomac River Bridge into Charles County, Maryland.

SR 2 and US 301 Business continue into the town of Bowling Green as Main Street.

[1][3] SR 2 continues north together with US 17 Business along Tidewater Trail, which crosses Massaponax Creek and passes through a suburban area on the south side of Fredericksburg.