The state highway runs 5.63 miles (9.06 km) from SR 42 in Timberville east to Interstate 81 (I-81) and U.S. Route 211 (US 211) in New Market.

SR 211 is a state-numbered westward extension of US 211.

The state highway heads east as two-lane undivided New Market Road, which parallels the North Fork Shenandoah River to the south.

The state highway passes to the south of New Market Airport and veers away from the river before meeting the southern end of SR 305 (George Collins Parkway), which provides access to the New Market Battlefield, which commemorates the Civil War Battle of New Market.

Old Cross Road continues east as US 211, which passes through New Market before heading toward Luray and Warrenton.