US 211 connects the Shenandoah Valley with the Piedmont town of Warrenton via Luray and Sperryville, where the highway runs concurrently with US 340 and US 522, respectively.

US 211 heads into the town as a four-lane divided highway that reduces to a two-lane undivided road prior to turning north onto US 11 (Congress Street).

US 211 becomes a three-lane road, with two lanes in the ascending direction and one on the descending side, for its curvaceous path over Massanutten Mountain, which summits at New Market Gap at the Shenandoah–Page county line.

US 340 splits north at a diamond interchange with Broad Street, which heads south into town as US 340 Business.

US 211 crosses over Norfolk Southern Railway's Hagerstown District line just west of its intersection with the east end of US 211 Business (Main Street).

[1][2] US 211 reduces to three lanes (two ascending, one descending) for its crossing of the Blue Ridge Mountains within Shenandoah National Park.

US 211 passes through Amissville and briefly through Culpeper County, where the highway meets the northern end of SR 229 (Rixeyville Road).

The highway enters the town of Warrenton as Frost Street south of Fauquier High School.

US 211 reaches its eastern terminus at Blackwell Road, which heads south as US 15 Business and north as SR 672.

Running from Warrenton through Manassas and Fairfax to the Highway Bridge over the Potomac River at Washington, D.C.

In July 1933, VA 21 was removed from the state highway system as part of a commonwealth-wide renumbering scheme.

The eastern terminus of US 211 was truncated from Washington, D.C., to its current end in Warrenton, leaving US 29 on that route.