Formed as a public–private partnership with the Carilion Clinic, the medical school grants the Doctor of Medicine (M.D.)

Initially a private institution from 2008 to 2018, the medical school became an official college of Virginia Tech in 2018.

The founding President and Dean of the medical school was Cynda Ann Johnson, who previously served as the Senior Associate Vice Chancellor at East Carolina University.

[5] In 2019, the LCME continued full accreditation for VTCSOM for eight years, the longest term granted.

[10] The Department of Neurosurgery was established in June 2023, following approval by the Virginia Tech Board of Visitors.

The basic science curriculum employs problem based learning groups that explore real patient cases from the community.

[17] VTC students take courses in biomedical research fundamentals, biostatistics, epidemiology, and ethics.