Prior to the formation of Virgos Merlot, many of the band members were in the group The Devine, which later disbanded.
The original lineup disbanded after the release of Signs of a Vacant Soul, with the band later reforming without guitarist Jason Marchant.
After touring with Creed as replacement live bassist for Brian Marshall, Brett Hestla joined Dark New Day in 2004.
In October 2008, it was stated by four of the original five band members, that they would reunite for a tenth anniversary, and a show was performed on January 9, 2009, in Birmingham, Alabama.
However, in November 2009, Ledbetter died from complications related to diabetes, leaving the future of the band unknown.