[1] Khomutynnik began his career in 1991, when he joined the State Enterprise Specialized Department of Reclamation and Mechanization of Construction.

[17] Khomutynnik was a business partner along with Pavel Fuks in a Ukrainian gas company called Ukrnaftoburinnya, usually associated with Ihor Kolomoyskyi.

[21][22][23] In 2019, Khomutynnik acquired a stake in Dmitry Firtash's Dresdenco Investments, after an approval by Antimonopoly Committee of Ukraine.

[27] In October 2015, Khomutynnik acquired a 5% stake in Ukraine's largest oil processor, Kernel Holding[28] (as of 2021, the company has a landbank of 514,000 hectares[29]).

In November 2017, Cascade Investment Fund, owned by Khomutynnik, increased its stake in Kernel Holding S. A. from 5% to 6.59%.

[30] In 2023 Kernel Holding announced the delisting of the company from Warsaw Stock Exchange[31] In 2018, the Antimonopoly Committee of Ukraine allowed Ukroagro Alliance Ltd and Kma Group Ltd to acquire a stake in the authorized capital of Dnipro Agro Alliance Ltd, which is located in the Dnipro region and covers more than 50 thousand hectares.

From May 1998 to April 2002 he was a deputy, and from September 1998 he was the chairman of the planning and budget commission of the Central City District Council of Makiivka.

Since April 2000, he has been the Minister of Fuel and Energy of the Youth Government of Ukraine, and since May 2000, a member of the ULIE Board.

[37][38] In 2017, Khomutynnik and his accompanied Russian-Ukrainian oligarch Pavel Fuks, known as his business partner, in the United States, in an attempt to attend First inauguration of Donald Trump.

53, Donetsk region, nominated by the Electoral Bloc of Political Parties For United Ukraine!).

Among the votes of his cadence was the second reading for the Law of Ukraine On the Principles of State Language Policy on August 10, 2012.

[42] As a member of the VII convocation of Verkhovna Rada of Ukraine (since December 2012) he was a head of Committee on Taxation and Customs Policy and head of Committee on Financial Policy and Banking and controlled taxation and VAT refunds.

[47] In a couple of months The General Prosecutor's Office of Ukraine closed the criminal proceedings on checking the declarations of Vitaliy Khomutynnik, no crime was established.

[36] During the parliamentary elections of 2014, observers of the Opora network recorded 2 bribes of voters with food packages from Khomutynnik, who ran for the 171 district of Kharkiv.