After his postdoctoral period, he joined the department of Physics of the University of Catania as an assistant professor in 2002.

Since 2012, Vito Latora is Full Professor in Applied Mathematics (Chair in Complex Systems) at the Queen Mary University of London.

Noteworthy, he has developed together with Massimo Marchiori the so-called "network efficiency",[2][3] a topological measure that accounts for the capability of a system to deliver information, or goods, spending the least amount of resources.

[7][8][9] As of March 2014, he is author of about 150 scientific papers and his h-index is equal to 50 according to Google Scholar.,[10] 38 according to Web of Science, and 37 according to Scopus.

[14] His work has been featured in many venues,[7][8][15][16][17][18] including being on the cover of the Physical Review Letters issue of 19 March 2010[15] He is editor of the Journal of Complex Networks since 2013.