[2][3][4][5] Karmali contested in the 1963 Goa, Daman and Diu Legislative Assembly election from the Curchorem Assembly constituency on the Maharashtrawadi Gomantak Party (MGP) ticket and emerged victorious.

Karmali was made the cabinet minister in the first Dayanand Bandodkar ministry and was allotted Law, Education and Public health as portfolios.

He then successfully contested in the 1967 Goa, Daman and Diu Legislative Assembly election from Siroda Assembly constituency on the MGP ticket and defeated United Goans (Sequiera Group) candidate, J. F. S. Fernandes by a margin of 3277 votes.

He served for few months from 1967 until his death in September 1967, following this a by-election was held in the constituency in 1968.

[6] Karmali died on 2 September 1967, he was remembered for his role in setting up large number of primary schools in Goa as the then education minister in Dayanand Bandodkar's ministry.