He would get a degree in medicine and begin working as a physician before entering politics, where he would become a prominent member of the Christian Democrats; making a name for himself in the field of foreign policy.

[3][4] He would face harsh criticism for his role as minister of defence after convicted Nazi Herbert Kappler escaped from Italian custody in 1977 to find sanctuary in West Germany.

[7][8][9] Following the kidnapping and death of fellow Apulia native Aldo Moro, Lattanzio effectively inherited the 'Apulian electoral fortune.

[11][12] While serving as Minister of Civil protection he would be criticized for inefficient handling of the department during the 1990 Augusta Earthquake.

[2][14] Lattanzio would be placed under house arrest while being investigated on allegations of corruption and illicit party financing.