Van den Assem completed the atheneum and followed a course in production support at the Netherlands Film and Television Academy.

After she started playing, dancing and singing at Jeugdtheater Hofplein from her thirteenth lessons, she got her first role in Goudkust[1] as Sophie Bergman.

In the period from 2004 to 2007 Van den Assem, together with Chris Silos, presented the television programme At Nick on Nickelodeon.

Van den Assem presented together with Chris Silos the Nickelodeon Netherlands Kids' Choice Awards of 2005, in 2007 she also did this, then together with Patrick Martens.

Van den Assem dubbed in 2007 of the penguin Lani in the Dutch version of the animated film Surf's Up.

[4] She also dubbed EVE in the Disney Pixar film WALL-E.[4] From 2008 Van den Assem performs the role of Sonja Zelenko in the Dutch crime series Deadline[1] (VARA).