It is based on the DC Comics character Mari McCabe / Vixen, a costumed superhero crime-fighter with the power to mimic the abilities of any animal that has ever lived on Earth.

[3] The series, described as an "origin story", is set in Detroit, Michigan and "prominently" features characters from Arrow and The Flash.

[16][17] Pedowitz also stated he regretted not airing the entire series as a half-hour special on The CW, something he hoped to do with season two.

Bonus features on the release include the Justice League Unlimited episodes "Hunter's Moon" and "Grudge Match" and a new featurette.

[22] In 2017, Vixen was nominated for the Golden Reel Award for Outstanding Achievement in Sound Editing – Computer Episodic (Webisode).

[13] Echikunwoke appeared as the character on Arrow during the fourth-season episode "Taken," in which Mari aided Oliver Queen and his team in rescuing his kidnapped son.

[17] It was originally intended for Echikunwoke to reprise her role in the second season of Legends of Tomorrow, but she was unable to do so due to previous commitments.

[25] Maisie Richardson-Sellers was ultimately cast to portray Amaya Jiwe, the grandmother of McCabe who also operated as Vixen.