The region consists of fours smaller micro-regions: Crna Trava, Znepolje, Lužnica and Vlasotince.

The largest center of the whole region is the town of Vlasotince, but in general, the area is one of the least developed in Serbia, very poor and extremely depopulating.

In 2005 Hellenic Bottling Co., a subsidiary of The Coca-Cola Company, bought the local water factory ("Rosa" is a trademark for this water) which is located close to the Vlasina source thus causing protests of the local environmentalists.

Activists from the "Eco base South" (Eko baza Jug) were afraid of overexploitation drying out the sources of the river.

In 2018 it was announced that European free-tailed bat, previously unrecorded in Serbia, was discovered living in Vlasina region.