Voghera railway station is situated at Piazzale Guglielmo Marconi, at the northern edge of the town centre.

The ticket office has a large plaque, placed in 1988, recalling the Vogherese rail workers who have fallen for freedom or on active service.

Near the newsstand, a plaque unveiled on the 40th anniversary of the 1962 train crash recalls the tragedy.

In a lateral building on the Genoa side are the office of the railway police and the public conveniences.

To serve the other tracks, there are three island platforms, all of them linked with the passenger building via three pedestrian underpasses.