Volodymyr Khandohiy graduated from the National Taras Shevchenko University of Kyiv and started his diplomatic career in 1975.

Khandohiy is a former Ambassador to Belgium and Luxembourg (2000-2005) and the Netherlands (2000-2002) and a former Head of the Mission of Ukraine to NATO (2000-2005).

[3][4] Khandohiy was the acting Minister of Foreign Affairs of Ukraine, after (on 3 March 2009) his predecessor Volodymyr Ohryzko was dismissed by the Ukrainian Parliament.

[5] On 9 October 2009 this parliament appointed Petro Poroshenko as foreign minister.

[2][6][7][8] In 2012 he said that Yevhen Khytrov was a victim of bad refereeing at the 2012 London Olympics.