He served as the Minister of Foreign Affairs of Ukraine from December 18, 2007 to March 3, 2009, when he was fired by the Ukrainian Parliament.

[2] On March 17, 2009 Ohryzko was appointed First Deputy Secretary of the National Security and Defense Council by President Viktor Yushchenko.

[3] Prime Minister Yulia Tymoshenko commented on the resignation: "If there were no crisis, he should have been dismissed long ago.

President Viktor Yushchenko called the dismissal of Ohryzko an "untimely and unfounded move from the Verkhovna Rada".

[8] After the resignation, in 2013, Ohryzko have said that it was a big mistake for Ukraine to pause the association agreement with the European Union.