Vonoprazan, sold under the brand name Voquezna among others, is a first-in-class potassium-competitive acid blocker medication.

[7][8] Vonoprazan is indicated for healing of all grades of erosive esophagitis and relief of heartburn associated with erosive esophagitis in adults; to maintain healing of all grades of erosive esophagitis and relief of heartburn associated with erosive esophagitis in adults; in combination with amoxicillin and clarithromycin for the treatment of Helicobacter pylori (H. pylori) infection in adults; in combination with amoxicillin for the treatment of H. pylori infection in adults.

[1][7][9] In July 2024, the indication was expanded in the US to include non-erosive gastroesophageal reflux disease.

[10] The most common side effects are constipation, diarrhea, enlarged feeling of abdomen, nausea, rash, and edema.

[1][11] Long-term use may lead to vitamin B12 deficiency, hypomagnesemia, and fundic gland polyps.