[14] It is not related to Byzantine Stauroupolis (ancient Aphrodisias) in Asia Minor, nor to the city of Stavropol-on-Volga (now called Tolyatti).

[4] Prince Grigory Potemkin, who founded Stavropol as one of ten fortresses built between Azov and Mozdok at the request of Catherine the Great, played a leading role in the creation of the city.

Don Cossacks, particularly those from the Khopersky Regiment, settled the area in and around the cities of Stavropol and Georgiyevsk with a mission to defend borders of the Empire.

[14][18] Stavropol experiences a humid continental climate (Dfa), using the 0°C (32°F) isotherm, with short but cold winters (though mild for Russia) and hot summers.

Gorbachev's chief mentor, long-time friend, and predecessor Yuri Andropov (1914–1984) was also born in Stavropol Krai.

He served in the cavalry units of the Russian army and he commanded the Buzhan Cossacks during the Russo-Turkish War of 1787–1791, he showed heroism during the assault on Ochakov and the defense of the Kinburn fortress.

[26] Major General Pavel Klimenko was born in Stavropol, he was killed during the Russian invasion of Ukraine in November 2024.

[27] Yevgeni Sergeyevich Dukhnov (born September 1986) former professional football player Stavropol is twinned with:[28]