Vy Maria Dong (born 1976 in Big Spring, Texas) is a Vietnamese-American Chancellor's Professor of Chemistry at the University of California, Irvine (UCI).

[5][6] Dong was born in Big Spring, Texas, in 1976, where she spent her early childhood, and moved with her family to Anaheim, California.

[8][9] Dong decided to study chemistry during her sophomore year after taking a class with Larry E. Overman, whom she later conducted undergraduate research with.

[13] Dong then moved back to UC Berkeley, working on supramolecular chemistry with Robert G. Bergman and Ken Raymond as a NIH Postdoctoral Fellow.

[14] Her work with Bergman and Raymond focused on the development of a supramolecular host molecule that can stabilize reactive iminium ions in water.

[19][20] Dong demonstrated that rhodium catalysis could be used to make cyclic peptides, using entirely achiral building blocks and hydrogenation catalysts.

Dong delivered the inaugural Eli Lilly Young lecture at the University of Wisconsin–Madison in 2009, where she discussed the catalytic transformations of C-H bonds.