WFYI-FM is a member of National Public Radio (NPR) and carries news and information programming, plus weekly shows featuring the Indianapolis Symphony the Indianapolis Chamber Orchestra, Harmonia, and the possible return of Classics by Request, Evening Concert, and Opera Hour.

IPS sold the station to Metropolitan Indianapolis Public Broadcasting in 1988, and on March 15, 1988, it changed its call sign to WFYI-FM.

Over time, the amount of classical music was decreased as the station added more news and informational programming.

WFYI is the home base of the health news service Side Effects Public Media.

WFYI 90.1 FM Public Radio carries services for the print-impaired via the Internet and a subcarrier (SCA) broadcast signal.