Weekdays on WIOD begin with two Florida-based talk shows, wake-ups with Ryan Gorman (from co-owned WFLA Tampa) and late mornings with station veteran Manny Munoz.

On weekends, specialty shows are heard on money, health, retirement, cars and pets, some of which are paid brokered programming.

Experimental broadcasts by Carl Graham Fisher, a Miami Beach developer, began in the spring of 1925.

[7] Fisher selected WIOD as the call sign, signifying the "Wonderful Isle of Dreams" to commemorate Collins Island, where studios and offices were located.

On February 7, 1925, an earlier station, WMBF, had been licensed to the Fleetwood Hotel Corporation in Miami Beach, with studios on the 16th floor.

In the 1950s, as network programming was moving from radio to television, WIOD switched to a full service format of middle of the road music (MOR), news and sports.

Branded Wacker Radio, it broadcast adult pop music by day, but offered Top 40 hits at night.

WIOD's former hosts include Larry King, Neil Rogers, Sally Jessy Raphael, Ron Bennington, Mike Reineri, Bill Calder, Alan Burke, Sandy Peyton, Rick and Suds, Hank Goldberg, Ed Berliner, Randi Rhodes, Big Wilson, Chris Baker, Phil Hendrie, Joey Reynolds, Tom Gauger, Dave LaMont, Tom Leykis, Jack Ellery and Ed Arnold.

Former full-time anchors include Mike Woulfe, Lori Shepard, Lauren Pastrana, Patty DeMendoza, Wendi Grossman, Andrew Julian, Ron Hersey, Aron Bender, Randy Lantz, Christina Kautz and John Levitt.

Reineri's traffic reporter, Dave Mitchell, hosted the show on Saturday and Sunday mornings in the same time slot.

Other traffic reporters on WIOD in the 1980s and 1990s and 2003-2007 were Miami radio veterans: Richard Lewis, Joe Brennan, George Sheldon, Teri Griffin and Don Anthony (Dave Agony from the WAXY FM days).

Other JAM jingle series that were reworked to accommodate the six-note WIOD logo include "The Spirit of New England," "New Day," "Superstation" and "New York Fan".