WMNF airs several progressive talk and news programs focused on LGBTQ issues, animal and environmental preservation and civil right, hosted mostly by volunteers.

Past public affairs programs included RadioActivity and The Women's Show, touching on feminist issues that first started running in the 1980s.

In 1986, WMNF began the first hip hop show in the area, The Kenny K Wax Attack, which aired on Saturdays at midnight.

[5] In 2014, WMNF added to the schedule, "The Rhythm Revival," hosted by nationally known recording artist/music historian Reverend Billy C. Wirtz.

In 2021, Marvelous Marvin, a longtime popular DJ on Tampa Bay commercial radio, joined the show as a cohost.

[citation needed] In 2007, WMNF moved to a higher antenna tower at 469 meters (1539 feet) in height above average terrain (HAAT).

[9] Then Program Director Randy Wynne indicated his belief that such difficulties arose after WMNF aired several criticisms against State Senator Grant's opposition to Olympic gold medalist diver and outspoken LGBTQ activist Greg Louganis attending a speaking engagement at the University of South Florida.

[10] On February 18, 2019, WMNF posted that they ended their "long-running relationship with News Director Rob Lorei" and for more information to "contact General Manager Craig Kopp.

There was a "public outcry" with "some supporters canceled donations"[12] and within the first few days comments from listeners and supporters "poured in at station meetings, and online via WMNF’s social media bulletin board"[13] Josh Holton, former WMNF board member and previous supporter of Craig Kopp wrote that he would no longer support him due to “the completely inappropriate manner in which he has handled this monumentally catastrophic decision, which has hurt our budget, our brand and our reputation.”[14] On March 18, 2019, the Board of Directors of WMNF posted a statement which said that they would "reinstate Rob to his role as News & Public Affairs Director at WMNF.

We believe that both Rob and Craig Kopp, the station general manager, can and should play a critical role in the present and future of WMNF.

It also has heightened our commitment to support the Tampa Bay community and to give a voice to the under-served.”[16]On April 15, 2019 WMNF's General Manager Craig Kopp resigned and noted the community’s reaction to the firing and re-hiring of Rob Lorei as a reason, alone with "anti-Semitic and other ‘toxic’ comments made"[17] Craig Kopp wrote: “I love WMNF as a concept and have dedicated myself to setting it up to continue far into the future ...

Rob Lorei denied using 'an ethnic slur' and said he used a 'political term' in a reply to a listener who wrote it to "downplay the dangers of the Proud Boys."