[2] WNDE broadcasts a sports radio format, with some afternoon talk programs, including The Clay Travis and Buck Sexton Show.

[3] Programming is also heard on the HD Radio digital subchannel of co-owned WFBQ 94.7 FM.

Former hosts of the afternoon drive local show include former WISH-TV sports anchor and Hoosier Millionaire host Mark Patrick, the team of Tim Bragg & Bill Benner, Indiana Pacers announcer Mark Boyle, JMV (John Michael Vincent, currently with WFNI), IndyCar Radio announcer Jake Query, and Derek Schultz.

And unusual for a sports radio station, it carries The Clay Travis and Buck Sexton Show from noon to 3 p.m.

On July 6, 2015, WNDE became the Indianapolis outlet for The Rush Limbaugh Show, which had been on WIBC for over two decades but whose carriage was ended for local programming.

Limbaugh began airing on WNDE the same day as the station rebranded to "Fox Sports 97.5.

When Limbaugh died in 2020, and Travis & Sexton succeeded him in the time slot, WNDE continued carrying the replacement program.

WNDE is the Indianapolis outlet for Purdue University football and men's basketball, sharing flagship status with Lafayette's WAZY.

After years of broadcasting Cincinnati Reds baseball, WNDE was briefly a part of the Chicago Cubs network in 2009 and 2010.

In 2011, WNDE dropped NASCAR programming after many years, and began broadcasting Indianapolis Indians baseball.