WXPO-TV, UHF analog channel 50, was an independent television station licensed to Manchester, New Hampshire, and serving Lowell, Massachusetts.

Its afternoon program, Treehouse 50, gained a cult following among Boston-area college students, as it featured slapstick comedy and the Warner Bros. Cartoons that had been released to television stations at that time.

The Lowell studio was located less than 1,000 feet from the WLLH transmitter, making high-quality production impossible during the day due to RF interference with the cameras.

In January 1970, in the wake of the failure of negotiations to bring in new investors and ameliorate channel 50's financial difficulties,[3] WXPO cut its broadcast day from 12 hours to 6 and dropped several local and syndicated shows.

Merrimack Valley Communications offered the WXPO-TV facility and permit for sale, including with ads in Broadcasting magazine;[6] at the end of December 1971, it filed with the Federal Communications Commission to sell majority control to Vendelco, Inc.[7] The FCC approved the transfer to Vendelco in August 1972.