The conference is named for the three rivers that drain in the area (Wa for Wapsipinicon, Ma for Maquoketa, and C for Cedar).
After a year of competing under that moniker, the league was renamed the WaMaC Conference to honor the three rivers that run through the region, the Wapsipinicon, the Maquoketa, and the Cedar.
After Regis left to join the larger Mississippi Valley Conference in 1992, Columbus Catholic in Waterloo replaced them.
Western Dubuque, Central DeWitt, Maquoketa, and Beckman were added to the league this year.
After originally being denied membership in the league, this expansion only occurred because the four schools petitioned to the state for inclusion in the WaMaC following the collapse of their former conference, the Big Bend.
The new 16 team league has gained much credibility at the end of the decade, due to the success of its schools.
In the 2009–10 academic year in girls' sports, Mount Vernon claimed the Class 2A State Volleyball Championship.
Solon also won the Class 3A State Baseball tournament, defeating Marion in the semifinals.
In girls' sports, Mount Vernon defeated West Delaware to capture the Class 3A State Championship in Volleyball, and capped a perfect season.
Columbus Catholic, Waterloo, claimed the Class 1A State Girls Tennis Championship.
[2] In the spring of 2019, Central DeWitt was admitted to the Mississippi Athletic Conference,[3] with the move effective in the fall of 2020, reducing the WaMaC to 13 teams.
In the summer of 2021, Maquoketa and Dyersville Beckman Catholic announced they planned to leave the WaMaC for the River Valley Conference.