Wachiraphayaban (Thai: วชิรพยาบาล) is a khwaeng (subdistrict) of Dusit District, in Bangkok, Thailand.

Most areas of Wachiraphayaban are in Samsen quarter, Samsen is an area with a long history before the establishment of Rattanakosin in 1782, since the Ayutthaya period in the reign of King Narai this was where the Immaculate Conception Church was located, and the Portuguese community.

Until the early Rattanakosin period, the Christian Khmers escape their country to settle here with the royal permission of the King Rama I.

The area is bordered by neighbouring subdistricts (from the north clockwise): Thanon Nakhon Chai Si in its district (Khlong Samsen is a borderline), Dusit in its district (Samsen Road is a borderline), Wat Sam Phraya of Phra Nakhon District (Khlong Phadung Krung Kasem is a borderline), (across the river) Bang Yi Khan and Bang Phlat of Bang Phlat District (midstream of Chao Phraya River is a borderline).

This article related to the city of Bangkok, Thailand is a stub.