During the 1930s, Mr. Tsui, himself a devout Catholic, saw the need of the pupils for greater spiritual guidance, and decided to gradually hand over the administration to the incoming Jesuits who were looking to serve in some local educational establishments.

Mr. Tsui left Hong Kong and became a successful rubber planter and hotelier in Kota Kinabalu, British North Borneo (now Sabah, Malaysia).

A South China Morning Post article in 1928 reported WYK to be the largest school in Hong Kong with a student population of 500.

Despite new facilities, however, seniors had to cross Victoria Harbour for laboratory lessons at the Wah Yan College, Hong Kong.

In 1941 when Hong Kong was attacked by the Japanese forces, the Jesuits of the college helped organise the evacuation of the Kowloon civilians to the Island as they closed down the school.

The Nelson Street campus was so thoroughly looted that Mr. Chow Ching-nam (周淸霖), then Principal, could only salvage a small portion of school registers and documents, and the students had to bring in their own chairs when the college reopened after the war.

After negotiations with the Government of Hong Kong, a piece of former paddy field was granted and it moved to the current premises on Waterloo Road in 1952.

[2][3] Mr. Laurence Tam (譚志成), an arts teacher during the late 1960s, pioneered a new Chinese ink painting movement which he integrated in his curriculum experimentally.