Wake Up with Whoopi was a morning radio show that aired on various stations in the United States from July 31, 2006 until March 28, 2008.
Discussion largely centered on water cooler topics as well as interviews with various guests, mostly from the entertainment industry.
At its peak, the program was heard on four of the top six major markets (New York's WKTU, Chicago's WLIT, San Francisco's KKSF and Philadelphia's WISX) and approximately twenty affiliates overall such as WAMO in Pittsburgh.
Opelka left to join Opie and Anthony; he was replaced by a team of Matt Bosso, Lisa Jackson, and Glenn Baker.
Cubby Bryant, who had been Goldberg's co-host, left the show in January 2008, staying on WKTU's morning drive.